Hyperpolarized 89Y complexes as pH sensitive NMR probes.
نویسندگان
چکیده
Hyperpolarization can increase the sensitivity of NMR/MRI experiments, but the primary limitation is the T(1) decay of magnetization. Due to its long T(1), the hyperpolarized (89)Y nucleus makes an excellent candidate as an in vivo spectroscopy/imaging probe. Here we report the (89)Y chemical shift dependence upon pH for two hyperpolarized (89)Y(III) complexes and demonstrate how such complexes can be used as sensitive spectroscopy/imaging agents to measure pH.
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 132 6 شماره
صفحات -
تاریخ انتشار 2010